Cursed (2005)
Cursed is a 2005 American horror-comedy film directed by Wes Craven and written by screenwriter Kevin Williamson, who both collaborated on Scream. The film stars Golden Globe nominees Christina Ricci and Jesse Eisenberg as the main sister-and-brother protagonists. The plot focuses on two young adults who are attacked by a werewolf loose in Los Angeles.
More at Wikipedia.