Angoroj (1964)
Angoroj (1964; Esperanto for "Agonies") was the first feature film to be produced entirely in Esperanto. It was directed and produced by Jacques-Louis Mahé, a friend of Raymond Schwartz who, under the pseudonym 'Lorjak', had previously produced a silent Esperanto publicity film before World War II titled Antaŭen! (Onwards!).
More at Wikipedia.